Recent findings regarding the cellular biology and immunology of BST‐2 (also known as tetherin) indicate that its function could be exploited as a universal replication inhibitor of enveloped respiratory viruses (e.g., influenza, respiratory syncytial virus, etc.). BST‐2 inhibits viral replication by preventing virus budding from the plasma membrane and by inducing an antiviral state in cells adjacent to infection via unique inflammatory signaling mechanisms. This review presents the first comprehensive summary of what is currently known about BST‐2 anti‐viral function against (...) respiratory viruses, how these viruses construct countermeasures to antagonize BST‐2, and how BST‐2 function might be targeted to develop therapies to treat respiratory virus infections. The authors address the current gaps in knowledge, including the need for mechanistic understanding of BST‐2 antagonism by respiratory viruses, that should be bridged to achieve that goal. (shrink)

Bundel essays over aspecten van het denken van de Duitse filosoof Martin Heidegger (1889-1976).

Evidence shows that changes in the architecture, design, and decor of health care facilities can improve patient care and in the long run reduce expenses. These essays detail the state of the research, look inside two hospitals that put some of these innovations into practice, and consider how design fits into the moral mission ofhealth care.

Highlights the central issues currently being debated within cultural anthropology, and documents the most original theoretical trends now affecting the field ...

Few years pass without an attempt to interpret Theocritus, Idyll 7. The poem's narrative and descriptive skill, dramatic subtlety and felicity of language are mercifully more than adequate to survive these scholarly onslaughts, so I have less hesitation in offering my own interpretation. The poem's chief problems seem to me to arise from uncertainty as to: Who is the narrator, and why are we kept waiting until line 21 before we are told that he is called Simichidas? Who, or what (...) sort of man, is the goatherd Lycidas, whom he encounters on his way from town to the harvest festival? Answers to these questions fundamentally affect our interpretation of their exchange of songs, which occupies almost half the idyll, and of Lycidas' gift of his stick to Simichidas; and these interpretations will go far towards interpreting the poem as a whole. (shrink)

post hos elefantorum fulgentium formidandam speciem et truculentos hiatus uix mentes pauidae perferebant; ad quorum stridorem odoremque et insuetum aspectum magis equi terrebantur. COKNELISSEN, Mnemosyne, xiv , 280, comments: ‘Non intellego fulgentium. Minime audiendus est Wagnerus, qui fulgentes elephantes dictos esse contendit ob cutem glabram. Corrigendum puto ingentium. Porro non satis intellego quomodo hiatus elefantorum militibus pauorem incutere potuerit. Wagnerus, qui omnia con-coquere solet, interpretatur proboscidas. Nescio an scripserit A. barritus.’.

The current article aims to provide an up-to-date synopsis of available techniques to study affect dynamics using intensive longitudinal data. We do so by introducing the following eight dichotomies that help elucidate what kind of data one has, what process aspects are of interest, and what research questions are being considered: single- versus multiple-person data; univariate versus multivariate models; stationary versus nonstationary models; linear versus nonlinear models; discrete time versus continuous time models; discrete versus continuous variables; time versus frequency domain; (...) and modeling the process versus computing descriptives. In addition, we discuss what we believe to be the most urging future challenges regarding the modeling of affect dynamics. (shrink)

This book is a clear, comprehensive guide to the philosophic and religious concepts of the world's outstanding philosophers. Here are the great thoughts and ideas of the Western mind, selected and explained with magnificent precision by an eminent scholar. It is an illuminating portrait of man's intellectual and moral struggle to understand the world and the meaning of human life and destiny. Plato Aristotle Augustine Aquinas Luther Descartes Kant Rousseau Marx Nietzsche.